Dr Tom Thorne
I am currently a Senior Lecturer in the Department of Computer Science at the University of Surrey.
Previously I was a Lecturer at the University of Reading, a Safra Research Fellow at Imperial College London, a Chancellor’s Fellow at the University of Edinburgh, and a postdoc in the Theoretical Systems Biology group at Imperial College London.
Research
My research focuses on applications of statistical methodologies to problems in Systems Biology and Bioinformatics, specifically:
- Graphical modelling of gene regulatory networks
- Statistical analysis of protein-protein interaction networks
- Approximate and likelihood free methods for inference
Publications and Software
Recent publications and preprints:
- Calibration of stochastic, agent-based neuron growth models with Approximate Bayesian Computation Duswald T, Breitwieser L, Thorne T, Wohlmuth B, Bauer R, Journal of Mathematical Biology 89 (5), 50, 2024.
- Shrinkage estimation of gene interaction networks in single-cell RNA sequencing data Vo DHT, Thorne T, BMC Bioinformatics 25 (1), 339, 2024.
- Identifying sub-populations of cells in single cell transcriptomic data – a Bayesian mixture modelling approach to zero-inflation of counts Wilson T, Vo DHT, Thorne T, Journal of Computational Biology 30 (10), 1059-1074, 2023. (preprint available here)
- Rare Event ABC-SMC2 Kerama I, Thorne T, Everitt RG, arxiv, 2022.
- Topological Approximate Bayesian Computation for Parameter Inference of an Angiogenesis Model Thorne T, Kirk PDW, Harrington HA, Bioinformatics, 2022.
Software:
- scmixture - Bayesian mixture modelling of single cell transcriptomics
- NetDiff - Bayesian model selection for differential gene regulatory network inference Thorne T, Scientific Reports, 6:39224, 2016. R package.
Group Members
PhD students:
- Marcela Akemi Ishihara – Visiting PhD student from Butantan Institute.
- Huan Huang – Systems biology analysis of data from GBM, with Dr Nelofer Syed.
- Duong Vo – Network inference from single cell data.
Past students:
- Ivis Kerama – PhD, with Dr Richard Everitt.
- Niharika Paul – LMS undergraduate research project.
- Tom Wilson – Summer research project.